{"id":30753,"date":"2023-10-08T13:19:56","date_gmt":"2023-10-08T05:19:56","guid":{"rendered":"\/\/www.562part.com\/?p=30753"},"modified":"2023-10-08T13:19:56","modified_gmt":"2023-10-08T05:19:56","slug":"listbio-%e7%99%be%e6%97%a5%e5%92%b3%e6%af%92%e7%b4%a0%ef%bc%88pertussis-toxin%ef%bc%8cptx%ef%bc%89","status":"publish","type":"post","link":"\/\/www.562part.com\/news\/30753\/","title":{"rendered":"listbio \u767e\u65e5\u54b3\u6bd2\u7d20\uff08Pertussis toxin\uff0cPTX\uff09"},"content":{"rendered":"

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0\"\"\u200b<\/span><\/p>\n

\u540c\u4e49\u540d\uff1a<\/strong><\/span><\/p>\n

Islet-activating protein, lymphocytosis-promoting factor, histamine-sensitizing factor, hemagglutinin, pertussigen , PTX, Holotoxin<\/span><\/p>\n

\u4e3b\u8981\u5e94\u7528\uff1a<\/strong><\/span><\/p>\n

PTX\u5e38\u4e0eMOG\uff0835-55\uff09\uff0cPLP\uff08139-151\uff09\uff0cPLP\uff08178-191\uff09\u7b49\u514d\u75ab\u80bd\u8054\u5408\u6ce8\u5c04\u52a8\u7269\uff0c\u4ece\u800c\u5efa\u7acb\u5b9e\u9a8c\u6027\u81ea\u8eab\u514d\u75ab\u6027\u8111\u810a\u9ad3\u708e\uff08Experimental Autoimmune Encephalomyelitis\uff0cEAE\uff09\u6a21\u578b\uff0c\u5373\u7528\u6765\u7814\u7a76\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08Mutiple sclerosis\uff0cMS\uff09\u7684\u6700\u5e38\u7528\u52a8\u7269\u6a21\u578b\u3002<\/span><\/p>\n

\u57fa\u672c\u4ecb\u7ecd\uff1a<\/strong><\/span><\/p>\n

\u767e\u65e5\u54b3\u6bd2\u7d20\uff08Pertussis toxin\uff0cPTX\uff09\u662f\u4e00\u79cd\u75316\u4e2a\u975e\u5171\u4ef7\u8fde\u63a5\u4e9a\u57fa\u7ec4\u6210\u7684\u591a\u5143\u4ef6\u86cb\u767d\uff0c\u5206\u5b50\u91cf\u8303\u56f4\u7ea6\u4e3a9-28kDa\uff0c\u8fd9\u4e9b\u4e9a\u57fa\u5206\u522b\u547d\u540d\u4e3aS1\uff0cS2\uff0cS3\uff0cS4\u548cS5\uff0c\u5929\u7136\u767e\u65e5\u54b3\u6bd2\u7d20\u4e2d\u6240\u5360\u6bd4\u4e3a1:1:1:2:1\uff0c\u5176\u4e2dS4\u4e9a\u57fa\u4ee52\u500d\u5f62\u5f0f\u5b58\u5728\u3002\u6700\u5927\u4e9a\u57fa\u4e3aS1\uff08\u4e5f\u79f0\u4e3aA\u542f\u52a8\u5b50\uff09\uff0c\u5305\u542bNAD+\u7cd6\u57fa\u6c34\u89e3\u9176\u548cADP-\u6838\u7cd6\u57fa\u8f6c\u79fb\u9176\u6d3b\u6027\u3002\u5355\u72ec\u7684A\u542f\u52a8\u5b50\u80fd\u591f\u5c06NAD+\u7684ADP\u6838\u7cd6\u8f6c\u79fb\u5230G\u03b1i\uff0cG\u03b1o\u6216G\u03b1t\u5bb6\u65cfG\u86cb\u767d\u7684\u03b1\u4e9a\u57fa\u3002PTX\u7684\u7ed3\u6676\u7ed3\u6784\u663e\u793a\u5176\u5448\u91d1\u5b57\u5854\u5f62\u72b6\uff0cA\u542f\u52a8\u5b50\u4f4d\u4e8e\u5854\u5c16\uff0c\u4e2d\u95f4\u662fS5\uff0c\u6700\u5e95\u7aef\u662f\u4e8c\u4e2a\u4e8c\u805a\u4f53\uff0c\u5206\u522b\u662fS2-S4,\u548cS3-S4\u3002\u8fd95\u4e2a\u4e9a\u57fa\u7edf\u79f0\u4e3aB\u5be1\u805a\u4f53\u4e9a\u57fa\uff08S2\uff0cS3\uff0cS4\uff0cS4\u548cS5\uff09\uff0c\u5141\u8bb8PTX\u8fdb\u5165\u5927\u90e8\u5206\u7ec6\u80de\uff0c\u4f7f\u5176\u7c98\u9644\u5728\u5305\u62ecTLR4\u548c\u7cd6\u86cb\u767dIb\u5728\u5185\u53d7\u4f53\u86cb\u767d\u7684\u591a\u7cd6\u6b8b\u57fa\u4e0a\u3002\u901a\u8fc7\u53d7\u4f53\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u8fdb\u5165\u7ec6\u80de\u540e\uff0cPTX\u901a\u8fc7\u80de\u5185\u4f53\u9014\u5f84\u548c\u9ad8\u5c14\u57fa\u4f53\u590d\u5408\u7269\u9006\u5411\u8f6c\u8fd0\u8fdb\u5165\u5185\u8d28\u7f51\u3002A\u542f\u52a8\u5b50\u4ecePTX\u4e0a\u91ca\u653e\u51fa\u6765\uff0c\u7a7f\u900f\u5185\u8d28\u7f51\u819c\u5e76\u5bfc\u81f4\u76ee\u6807\u819c\u5076\u8054\u7684G\u86cb\u767d\u5931\u6d3b\u3002<\/span><\/p>\n

\u751f\u7406\u529f\u80fd\uff1a<\/strong><\/span><\/p>\n

\u767e\u65e5\u54b3\u6bd2\u7d20\uff08Pertussis toxin\uff0cPTX\uff09\u7531Bordetella pertussis\u4ee3\u8c22\u7eaf\u5316\u6240\u5f97\uff0c\u4e00\u79cd\u591a\u4e9a\u57fa\u6bd2\u7d20\uff0c\u4e0e\u5927\u591a\u6570\u54fa\u4e73\u52a8\u7269\u57f9\u517b\u7ec6\u80de\u7ed3\u5408\u5e76\u7279\u5b9a\u9776\u5411G\u86cb\u767d\uff0c\u6291\u5236G\u86cb\u767d\u53ca\u5176\u5728\u4fe1\u53f7\u901a\u8def\u4e2d\u7684\u751f\u7406\u529f\u80fd\u3002PTX\u7684\u751f\u7406\u6548\u5e94\u56e0G\u86cb\u767d\u529f\u80fd\u4e0d\u540c\u800c\u53d8\u5316\u3002\u6b63\u662f\u4f9d\u8d56Gi\u5bb6\u65cf\u7684\u86cb\u767d\u5076\u8054\u53d7\u4f53\u6765\u6291\u5236\u4fe1\u53f7\u901a\u8def\u7684\u80fd\u529b\uff0cPTX\u662f\u7ec6\u80de\u751f\u7269\u5b66\u7814\u7a76\u4e2d\u7684\u4e00\u79cd\u91cd\u8981\u5de5\u5177\u3002PTX\u901a\u8fc7\u6291\u5236\u548c\u8c03\u8282\u5404\u79cd\u5bbf\u4e3b\u5bf9Bordetella pertussis\u7684\u514d\u75ab\u53cd\u5e94\u5728\u4f20\u67d3\u65b9\u9762\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u9f20\u7c7b\u52a8\u7269\u6a21\u578b\u4e2dPTX\u8fd8\u80fd\u7528\u6765\u523a\u6fc0\u5efa\u7acb\u5b9e\u9a8c\u6027\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff0c\u6bd4\u5982\u5b9e\u9a8c\u6027\u81ea\u8eab\u514d\u75ab\u6027\u8111\u810a\u9ad3\u708e\uff08Experimental Autoimmune Encephalomyelitis\uff0cEAE\uff09\u6a21\u578b\u3002<\/span><\/p>\n

\u57fa\u672c\u53c2\u6570\uff1a<\/strong><\/span><\/p>\n

1\uff09\u00a0CAS NO\uff1a82248-93-9<\/span><\/p>\n

2\uff09\u00a0\u7eaf\u5ea6\uff1a>95%\uff08This product migrates as five distinct bands when run on a 16%Tricine\u00a0gelsin the presence of a reducing agent. The five bands consist of one A protomer subunit (S1, MW=26.2 kDa) and four B oligomer subunits (S2, S3, 2x S4, S5). Densitometric analysis estimates the purity as >95%.\uff09<\/span><\/p>\n

This product has been tested for endotoxin levels and was found to be acceptable.<\/span><\/p>\n

3\uff09\u00a0\u751f\u7269\u6d3b\u6027\uff1a<\/span><\/p>\n

a\uff09CHO\u7ec6\u80de\u5b9e\u9a8c\u2014\u4f9d\u7167Hewlett et al.\u65b9\u6cd5\uff0c\u4ea7\u751f\u9633\u6027\u53cd\u5e94\uff08CHO\u7c07\u805a\u751f\u957f\u6a21\u5f0f\uff09\u6240\u9700PTX\u7684\u6700\u4f4e\u6d53\u5ea6\u4e3a0.03ng\/ml\uff1b\u4f9d\u6279\u6b21\u4e0d\u540c\u800c\u6709\u53d8\u5316\u3002<\/span><\/p>\n

b\uff09\u817a\u82f7\u9178\u73af\u5316\u9176\u5b9e\u9a8c\uff1a\u4f9d\u7167Wolff et al\u65b9\u6cd5\uff0c\u5728\u542b1 \u03bcM\u9499\u8c03\u86cb\u767d\u7684\u4f53\u7cfb\u4e2d\uff0cPTX\u7684\u817a\u82f7\u9178\u73af\u5316\u9176\u6d3b<\/span><\/p>\n

\u6027\u662f9\u00a0picomoles\/min\/\u03bcg\u3002\u4f9d\u7167\u6279\u6b21\u4e0d\u540c\u4f1a\u6709\u5dee\u5f02\u3002<\/span><\/p>\n

\u4ea7\u54c1\u4fe1\u606f<\/strong><\/span><\/p>\n

List labs\u63d0\u4f9b\u4e09\u79cd\u914d\u65b9\u5f62\u5f0f\u7684\u767e\u65e5\u54b3\u6bd2\u7d20\uff08Pertussis toxin\uff0cPTX\uff09\uff0c\u5206\u522b\u662f\u7518\u6cb9\u6eb6\u6db2\uff08\u8d27\u53f7\uff1a179\uff09\uff0c\u6eb6\u4e8e\u7f13\u51b2\u6db2\u7684\u51bb\u5e72\u7c89\uff08\u8d27\u53f7\uff1a180\uff09\uff0c\u4ee5\u53ca\u6eb6\u4e8e\u7eaf\u6c34\u7684\u51bb\u5e72\u7c89\uff08\u8d27\u53f7\uff1a181\uff09\u3002\u90e8\u5206\u73b0\u8d27\u4f9b\u5e94\uff0c\u539f\u88c5\u8fdb\u53e3\uff0c\u6b22\u8fce\u6765\u7535\u54a8\u8be215901969288\u3002<\/span><\/p>\n\n\n\n\n\n\n
\n

\u54c1\u724c<\/span><\/p>\n<\/td>\n

\u4ea7\u54c1\u540d\u79f0<\/span><\/td>\n\u8d27\u53f7<\/span><\/td>\n\u89c4\u683c<\/span><\/td>\n\u8d27\u671f<\/span><\/td>\n<\/tr>\n
\n

List Biologicallaboratorial<\/span><\/p>\n<\/td>\n

\n

Pertussis Toxin from B. pertussis, Lyophilized in Buffer<\/span><\/p>\n<\/td>\n

180<\/span><\/td>\n50 \u00b5g<\/span><\/td>\n\u73b0\u8d27<\/span><\/td>\n<\/tr>\n
Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)<\/span><\/td>\n181<\/span><\/td>\n50 \u00b5g<\/span><\/td>\n\n

\u73b0\u8d27<\/span><\/p>\n<\/td>\n<\/tr>\n

Pertussis Toxin from B. pertussis (in Glycerol)<\/span><\/td>\n179<\/span><\/td>\n50 \u00b5g<\/span><\/td>\n\n

\u54a8\u8be2<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u5173\u4ea7\u54c1<\/strong><\/span><\/p>\n\n\n\n\n\n
\n

\u54c1\u724c<\/span><\/p>\n<\/td>\n

\u4ea7\u54c1\u540d\u79f0<\/span><\/td>\n\u8d27\u53f7<\/span><\/td>\n\u89c4\u683c<\/span><\/td>\n\u8d27\u671f<\/span><\/td>\n<\/tr>\n
\n

List Biologicallaboratorial<\/span><\/p>\n<\/td>\n

Pertussis Toxin Mutant<\/span><\/td>\n184<\/span><\/td>\n50 \u00b5g<\/span><\/td>\n\n

\u54a8\u8be2<\/span><\/p>\n<\/td>\n<\/tr>\n

Pertussis Toxin\u00a0A promoter<\/span><\/td>\n182<\/span><\/td>\n10 \u00b5g<\/span><\/td>\n\n

\u54a8\u8be2<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u6ce8\u610f\u4e8b\u9879<\/strong><\/span><\/p>\n

1\uff09\u00a0\u672c\u54c1\u4ec5\u7528\u4f5c\u79d1\u7814\u7814\u7a76\uff0c\u7531\u4e13\u4e1a\u7684\u79d1\u5b66\u4eba\u58eb\uff0c\u5e76\u5728\u6b63\u89c4\u7684\u5b9e\u9a8c\u5ba4\u5185\u64cd\u4f5c\u3002\u7edd\u4e0d\u53ef\u7528\u4f5c\u5176\u4ed6\u7528\u9014\uff08\u6bd4\u5982\u4e34\u5e8a\u836f\u7269\u3001\u517d\u836f\u3001\u8bca\u65ad\u7528\u9014\u7b49\uff09\uff01\uff01<\/strong><\/span><\/p>\n

2\uff09\u00a0\u4e3a\u4e86\u60a8\u7684\u5b89\u5168\u548c\u5065\u5eb7\uff0c\u8bf7\u7a7f\u5b9e\u9a8c\u670d\u5e76\u6234\u4e00\u6b21\u6027\u624b\u5957\u64cd\u4f5c\u3002<\/span><\/p>\n

\n","protected":false},"excerpt":{"rendered":"

PTX\u5e38\u4e0eMOG\uff0835-55\uff09\uff0cPLP\uff08139-151\uff09\uff0cPLP\uff08178-191\uff09\u7b49\u514d\u75ab\u80bd\u8054\u5408\u6ce8\u5c04\u52a8\u7269\uff0c\u4ece\u800c\u5efa\u7acb\u5b9e\u9a8c\u6027\u81ea\u8eab\u514d\u75ab\u6027\u8111\u810a\u9ad3\u708e\uff08Experimental Autoimmune Encephalomyelitis\uff0cEAE\uff09\u6a21\u578b\uff0c\u5373\u7528\u6765\u7814\u7a76\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08Mutiple sclerosis\uff0cMS\uff09\u7684\u6700\u5e38\u7528\u52a8\u7269\u6a21\u578b\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,51],"tags":[],"_links":{"self":[{"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/posts\/30753"}],"collection":[{"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/comments?post=30753"}],"version-history":[{"count":1,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/posts\/30753\/revisions"}],"predecessor-version":[{"id":30754,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/posts\/30753\/revisions\/30754"}],"wp:attachment":[{"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/media?parent=30753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/categories?post=30753"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/tags?post=30753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}