{"id":17459,"date":"2019-08-17T17:58:12","date_gmt":"2019-08-17T09:58:12","guid":{"rendered":"\/\/www.562part.com\/?p=17459"},"modified":"2019-11-08T10:48:19","modified_gmt":"2019-11-08T02:48:19","slug":"bleomycins-blms-%e5%8d%9a%e8%8e%b1%e9%9c%89%e7%b4%a0%e5%ae%b6%e6%97%8f%e5%b8%b8%e7%94%a8%e6%8a%97%e7%94%9f%e7%b4%a0%e6%88%90%e5%91%98%e7%9a%84%e5%ba%94%e7%94%a8%e9%80%89%e6%8b%a9","status":"publish","type":"post","link":"\/\/www.562part.com\/tech-features\/17459\/","title":{"rendered":"Bleomycins (BLMs) \u535a\u83b1\u9709\u7d20\u5bb6\u65cf\u5e38\u7528\u6297\u751f\u7d20\u6210\u5458\u7684\u5e94\u7528\u9009\u62e9"},"content":{"rendered":"

\u25c7\u25c7 Bleomycin Sulfate \u786b\u9178\u535a\u83b1\u9709\u7d20\uff1bBleomycin A5 Hydrochloride \u76d0\u9178\u5e73\u9633\u9709\u7d20\uff1b<\/strong><\/span><\/p>\n

\u25c7\u25c7 Zeocin \u535a\u83b1\u9709\u7d20\uff1bPhleomycin \u8150\u8349\u9709\u7d20\uff1b<\/strong><\/span><\/p>\n

 <\/p>\n

\u57fa\u672c\u6982\u5ff5\uff1a<\/strong><\/span><\/p>\n

\u535a\u83b1\u9709\u7d20\uff08\u535a\u6765\u9709\u7d20\uff09\uff08Bleomycins, BLMs\uff09\uff0c\u7531\u8f6e\u679d\u94fe\u9709\u83cc\uff08Streptomyces verticillus\uff09\u4ee3\u8c22\u4ea7\u751f\u7684\u4e00\u79cd\u6297\u80bf\u7624\u7cd6\u80bd\u6297\u751f\u7d20\uff0c\u662f\u4e34\u5e8a\u4e0a\u76f8\u5173\u7684\u5929\u7136\u4ea7\u7269\uff0c\u7528\u4e8e\u5316\u7597\u6cbb\u7597\u6dcb\u5df4\u7624\u3001\u9cde\u72b6\u7ec6\u80de\u764c\u548c\u777e\u4e38\u764c\u3002BLMs\u901a\u8fc7\u4e00\u79cd\u91d1\u5c5e\u4f9d\u8d56\u7684\u673a\u5236\u5f15\u8d77\u5e8f\u5217\u7279\u5f02\u6027\u7684\u6c27\u5316\u5207\u5272dsDNA\u3002BLMs\u542b4\u4e2a\u529f\u80fd\u7ed3\u6784\u57df\uff1ai\uff09\u5305\u542b\u5627\u5576\u535a\u83b1\u9178\uff08pyrimidoblamic acid\uff09\u548c\u03b2-\u7f9f\u57fa\u7ec4\u6c28\u9178\u7684\u91d1\u5c5e\u7ed3\u5408\u57df\uff1bii\uff09\u7531\u4e8c\u567b\u5511\u90e8\u5206\u548c\u4e0e\u5627\u5576\u80fa\u73af\u76f8\u4e92\u4f5c\u7528\u7684C\u7aef\u80fa\u57fa\u5c3e\u90e8\u6784\u6210\u7684DNA\u7ed3\u5408\u57df\uff1biii\uff09\u8fde\u63a5\u91d1\u5c5e\u548cDNA\u7ed3\u5408\u57df\u7684\u4e00\u8fde\u63a5\u533a\u57df\uff1b\u4ee5\u53caiv\uff09\u8d1f\u8d23\u7ec6\u80de\u9009\u62e9\u6027\u548cDNA\u65ad\u88c2\u6d3b\u6027\u7684\u4e8c\u7cd6\u90e8\u5206[1]\u3002\u3010\u6587\u732e1\uff1aCoughlin JM et al. BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin. Biochemistry. 2014 Nov 11;53(44):6901-9.\u3011<\/span><\/p>\n

\u4e00\u3001\u786b\u9178\u535a\u83b1\u9709\u7d20\uff08Bleomycin Sulfate\uff09\u4e0e\u76d0\u9178\u5e73\u9633\u9709\u7d20\uff08Bleomycin A5 Hydrochloride\uff09<\/strong><\/span><\/p>\n

\u25a1 \u7528\u9014\uff1a\u6297\u80bf\u7624\u836f\u7269\uff08Anticancer agent\uff09<\/strong><\/span><\/p>\n

\u5e73\u9633\u9709\u7d20\u548c\u535a\u83b1\u9709\u7d20\u901a\u5e38\u4e0e\u5176\u4ed6\u6297\u80bf\u7624\u5242\u8054\u5408\u4f7f\u7528\u5728\u4e34\u5e8a\u4e0a\u7528\u6765\u6cbb\u7597\u777e\u4e38\u764c\u3001\u5375\u5de2\u764c\u3001\u5b50\u5bab\u9888\u764c\u3001\u5934\u9888\u764c\u3001\u98df\u9053\u764c\u3001\u7532\u72b6\u817a\u764c\u548c\u6dcb\u5df4\u7624\u3002<\/span><\/p>\n

1.1 \u4e24\u79cd\u6297\u751f\u7d20\u7684\u7ed3\u6784\u7279\u5f81<\/strong><\/span><\/p>\n

\u5e73\u9633\u9709\u7d20\uff08Pingyangmycin\uff09\uff0c\u4e5f\u79f0\u4e3a\u535a\u83b1\u9709\u7d20A5\uff08Bleomycin A5\uff09\uff0c\u662f\u535a\u83b1\u9709\u7d20\u5bb6\u65cf\u6210\u5458\u4e4b\u4e00\u3002\u4e8e1969\u5e74\u53d1\u73b0\u4e8e\u4e2d\u56fd\u6d59\u6c5f\u5e73\u9633\u53bf\uff0c\u4e4b\u540e\u4e8e1978\u5e74\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\uff08SFDA\uff09\u6388\u6743\u7528\u4e8e\u4e34\u5e8a\u7528\u9014\u3002<\/span><\/p>\n

\u535a\u83b1\u9709\u7d20\uff08Bleomycin, BLM\uff09\u4e8e1962\u5e74\u53d1\u73b0\uff0c\u4e8e1969\u5e74\u5728\u65e5\u672c\u6388\u6743\u4e3a\u6297\u80bf\u7624\u836f\u7269\uff0c\u4e5f\u57281973\u5e74\u83b7US FDA\u8bb8\u53ef\u7528\u4e8e\u4e34\u5e8a\u836f\u3002BLM\u662f\u4e24\u79cd\u4e3b\u8981\u6210\u5206\u6784\u6210\u7684\u6df7\u5408\u7269\uff0c\u535a\u83b1\u9709\u7d20A2\uff0855-70%\uff09\u548cB2\uff0825-32%\uff09\u3002<\/span><\/p>\n

\u535a\u83b1\u9709\u7d20A2\u3001B2\u548cA5\u7ed3\u6784\u89c1\u56fe1\uff0c\u4e09\u4e2a\u5316\u5408\u7269\u5177\u6709\u76f8\u540c\u7684\u5316\u5b66\u9aa8\u67b6\uff0c\u4f46\u4e0d\u540c\u7684\u5e26\u6b63\u7535\u8377R\u57fa\u56e2\u3002\u51e0\u79cd\u8f6c\u8fd0\u4f53\u8d1f\u8d23\u6444\u53d6\u5e26\u6b63\u7535\u8377\u7684BLMs\u3002\u4e00\u65e6\u8fdb\u5165\u7ec6\u80de\uff0cBLMs\u7684\u6297\u80bf\u7624\u6d3b\u6027\u53d6\u51b3\u4e8e\u5b83\u4eec\u4ea7\u751fRNA\u548cDNA\u65ad\u88c2\u7684\u80fd\u529b\uff0c\u5f15\u8d77\u7ec6\u80de\u6b7b\u4ea1\u3002<\/span><\/p>\n

\"\"<\/span><\/p>\n

\u56fe1. \u535a\u83b1\u9709\u7d20A2\u3001B2\u548cA5\u7684\u5316\u5b66\u7ed3\u6784\u56fe\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

1.2 \u4e24\u79cd\u6297\u751f\u7d20\uff08\u4e09\u4e2a\u5316\u5408\u7269\uff09\u7684\u836f\u7406\u7279\u5f81<\/strong><\/span><\/p>\n

He Y et al.[2]\u5bf96\u79cd\u4e0d\u540c\u7684\u7ec6\u80de\u7cfb\uff0c\u5305\u62ec\u4e00\u79cd\u72ec\u7279\u7684CHO\u7a81\u53d8\u7ec6\u80de\uff08GAG\u751f\u7269\u5408\u6210\u7f3a\u9677\uff09\u6bd4\u8f83\u535a\u83b1\u9709\u7d20A2\u3001B2\u548cA5\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u5206\u5b50\u673a\u5236\uff0c\u7ec6\u80de\u6bd2\u6027\u6570\u636e\u8868\u660eGAGs\u53ef\u80fd\u662fBLMs\u7684\u7ec6\u80de\u6444\u53d6\u53d7\u4f53\u3002\u800cBLM\u548cA5\u4f5c\u7528\u4e0bEGFR\u8868\u8fbe\u548c\u78f7\u9178\u5316\u7684\u4e0b\u8c03\u8bf4\u660e\uff0c\u4e0d\u540c\u7684BLMs\u5177\u6709\u76f8\u540c\u7684\u5206\u5b50\u673a\u5236\u6765\u8bf1\u5bfc\u7ec6\u80de\u6bd2\u6027\uff08\u57fa\u4e8e\u7ec6\u80de\u5468\u671f\u6570\u636e\u3001\u53c2\u4e0e\u7ec6\u80de\u5468\u671f\u3001\u51cb\u4ea1\u548c\u5176\u4ed6\u8fc7\u7a0b\u91cd\u8981\u86cb\u767d\u7684\u514d\u75ab\u5370\u8ff9\u5206\u6790\uff09\u3002\uff08\u6587\u732e2\uff1aHe Y et al. Pingyangmycin and Bleomycin Share the Same Cytotoxicity Pathway. Molecules. 2016 Jun 30;21(7).\uff09from maokangbio<\/span>)<\/span><\/p>\n

\u5728\u4e2d\u56fd\uff0c\u535a\u83b1\u9709\u7d20A5\u66f4\u591a\u66ff\u4ee3BLM\u7528\u4f5c\u4e00\u79cd\u6297\u80bf\u7624\u836f\uff0c\u56e0\u7ec4\u5206\u5355\u4e00\u4e14\u4ef7\u683c\u66f4\u4fbf\u5b9c\uff0c\u66f4\u91cd\u8981\u7684\u662fA5\u662f\u6709\u6548\u7684\uff0c\u867d\u7136\u5728\u80bf\u7624\u7ec6\u80de\u4e0a\u5e76\u672a\u6bd4BLM\u66f4\u4f18\u79c0\u3002\u7684\u786e\uff0c\u672c\u6587\u4e2dA5\u7684\u7ec6\u80de\u6bd2\u6027\u548cIC50\u6570\u636e\u4e5f\u8868\u660e\u5176\u5728\u6240\u6709\u80bf\u7624\u548cCHOK1\u7ec6\u80de\u7cfb\uff08\u9664CHO745\uff09\u6bd2\u6027\u66f4\u5f3a\uff08\u89c1\u56fe2\uff09\u3002\u6709\u610f\u601d\u7684\u662f\uff0cA2\u548cB2\u5728CHO745\u4e2d\u7684\u6bd2\u6027\u660e\u663e\u5f3a\u4e8eA5\u3002\u8fdb\u4e00\u6b65\u8bf4\u660eGAGs\u53ef\u80fd\u662f\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u5185\u8d1f\u8d23BLM\u6444\u53d6\u7684\u53d7\u4f53\u3002<\/span><\/p>\n

\"\"<\/span><\/p>\n

\u56fe2. Growth inhibitory effect of BLMs on A549, H1299, HCT116, HT29, CHO745 and CHOK1 cell lines. Two human lung cancer cell lines A549 and H1299, two human colon cancer cell lines HCT116 and HT29, and two Chinese hamster ovary cell lines (CHO745 and CHOK1) were used to measure the percentage of viable cells after 48 h exposure to 0\u2013160 \u03bcM BLM (A2B2), A2, B2, A5, A2A5 and B2A5. The experiment was repeated three times with similar results. The untreated cells (control) were assigned values of 100 and the results were presented as mean \u00b1 S.D. (n\u00a0= 3). Different letters (a, b, or c) in each concentration group mean significant differences (ANOVA with Tukey test for multiple comparisons,\u00a0p\u00a0< 0.05).<\/span><\/p>\n

\u4e8c\u3001\u535a\u83b1\u9709\u7d20\uff08Zeocin\uff09\u548c\u8150\u8349\u9709\u7d20\uff08Phleomycin\uff09<\/strong><\/span><\/p>\n

\u25a1 \u7528\u9014\uff1a\u7b5b\u9009\u6297\u751f\u7d20\uff08selection antibiotic\uff09<\/strong><\/span><\/p>\n

2.1 \u4e24\u79cd\u6297\u751f\u7d20\u7684\u57fa\u672c\u4ecb\u7ecd<\/strong><\/span><\/p>\n

\u8150\u8349\u9709\u7d20\uff08Phleomycin\uff09\u662f\u4e00\u79cd\u7cd6\u80bd\u7c7b\u6297\u751f\u7d20\uff0c\u7ed3\u6784\u4e0a\u7c7b\u4f3c\u4e8e\u6297\u751f\u7d20Bleomycin (BLM)\u3002\u7eaf\u5316\u7684\u8150\u8349\u9709\u7d20\u4e3b\u8981\u7531\u8150\u8349\u9709\u7d20D1\uff08Phleomycin D1\uff09\uff08\u672b\u7aef\u80fa\u57fa\u662f\u80cd\u4e01\u80fa\uff09\u4ee5\u94dc\u79bb\u5b50\u87af\u5408\u548c\u76d0\u9178\u76d0\u5f62\u5f0f\u63d0\u4f9b\u3002\u8150\u8349\u9709\u7d20\u963b\u65ad\u7ec6\u80de\u5468\u671f\u8fdb\u5165S\u671f\uff0c\u867d\u7136\u8150\u8349\u9709\u7d20\u7c7b\u4f3c\u4e8eBleomycin\uff0c\u80fd\u7834\u574fDNA\uff0c\u4f46\u4e0d\u7528\u4f5c\u4e00\u79cd\u6297\u80bf\u7624\u5242\u3002<\/strong>\u76ee\u524d\u8150\u8349\u9709\u7d20\u7684\u4f5c\u7528\u673a\u7406\u5e76\u672a\u5b8c\u5168\u5f97\u4ee5\u9610\u660e\uff0c\u636e\u62a5\u9053\u7531\u4e8e\u4fee\u9970\u7684\u4e8c\u567b\u5511\u90e8\u5206\uff0c\u5176\u4e0d\u80fd\u63d2\u5165DNA\u3002RAD6 DNA\u4fee\u590d\u57fa\u56e0\u5728\u7a81\u53d8\u9175\u6bcd\u5185\u5bf9\u8150\u8349\u9709\u7d20\u6297\u6027\u662f\u5fc5\u987b\u7684\u3002\u5206\u5b50\u9057\u4f20\u5b9e\u9a8c\u4e2d\u8150\u8349\u9709\u7d20\u7528\u4f5c\u4e00\u79cd\u9009\u62e9\u6027\u6297\u751f\u7d20\uff0c\u5176\u5177\u5e7f\u8c31\u7684\u6bd2\u6027\uff0c\u5bf9\u7ec6\u83cc\u3001\u771f\u6838\u5fae\u751f\u7269\u548c\u690d\u7269\u548c\u52a8\u7269\u7ec6\u80de\u5448\u4f53\u5185\u6d3b\u6027\u3002\u8150\u8349\u9709\u7d20\u56e0\u6b64\u80fd\u7528\u4e8e\u9274\u5b9a\u548c\u7b5b\u9009\u542b\u8150\u8349\u9709\u7d20\u6297\u6027\u57fa\u56e0\u6bd4\u5982Sh ble\u57fa\u56e0\u7684\u5404\u79cd\u7ec6\u80de\u3002<\/span><\/p>\n

 <\/p>\n

Zeocin\u2122\u662f\u535a\u83b1\u9709\u7d20\/\u8150\u8349\u9709\u7d20\uff08bleomycin\/phleomycin\uff09\u6297\u751f\u7d20\u5bb6\u65cf\u7684\u6210\u5458\u4e4b\u4e00\uff0c\u4ece\u8f6e\u679d\u94fe\u9709\u83ccStreptomyces verticillus\u4e2d\u5206\u79bb\u5f97\u5230\uff0c\u5bf9\u7ec6\u83cc\u3001\u771f\u83cc\uff08\u5305\u62ec\u9175\u6bcd\u83cc\uff09\u3001\u690d\u7269\u548c\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u5177\u5f88\u5f3a\u7684\u6bd2\u6027\u3002Zeocin\u2122\u662f\u8150\u8349\u9709\u7d20D1\u7684\u5546\u4e1a\u540d\u79f0\uff0c\u4e00\u79cd\u78b1\u6027\u3001\u6c34\u6eb6\u6027\u3001\u94dc\u79bb\u5b50\u87af\u5408\u7684\u7cd6\u80bd\u6297\u751f\u7d20\u3002\u94dc\u79bb\u5b50\u7684\u5b58\u5728\u4f7f\u5f97\u6eb6\u6db2\u4e3a\u84dd\u8272\uff0c\u6b64\u94dc\u87af\u5408\u7684\u5f62\u5f0f\u4e3a\u65e0\u6d3b\u6027\u3002\u4e00\u65e6\u8fdb\u5165\u7ec6\u80de\u540e\uff0c\u4e8c\u4ef7\u94dc\u79bb\u5b50\uff08Cu2+\uff09\u88ab\u8fd8\u539f\u4e3a\u4e00\u4ef7\u94dc\u79bb\u5b50\uff08Cu+\uff09\uff0c\u5e76\u88ab\u7ec6\u80de\u5185\u7684\u5def\u57fa\u5316\u5408\u7269\u53bb\u9664\u3002\u94dc\u79bb\u5b50\u88ab\u53bb\u9664\u540e\uff0cZeocin\u2122\u88ab\u6d3b\u5316\uff0c\u5d4c\u5165DNA\u4f7f\u5176\u65ad\u88c2\uff0c\u6700\u7ec8\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002<\/span><\/p>\n

 <\/p>\n

2.2 \u4e24\u79cd\u6297\u751f\u7d20\u7684\u5e94\u7528\u5dee\u5f02<\/strong><\/span><\/p>\n

\u8150\u8349\u9709\u7d20\uff08Phleomycin\uff09\u548cZeocin\u2122\u90fd\u5c5e\u4e8e\u535a\u83b1\u9709\u7d20\/\u8150\u8349\u9709\u7d20\uff08bleomycin\/phleomycin\uff09\u6297\u751f\u7d20\u5bb6\u65cf\u7684\u6210\u5458\uff0c\u540e\u8005\u662f\u5bf9Phleomycin D1\u7684\u5546\u4e1a\u540d\u79f0\u3002\u8fd9\u4e24\u79cd\u6297\u751f\u7d20\u90fd\u7528\u4f5c\u7b5b\u9009\u6297\u751f\u7d20\uff0c\u5206\u5b50\u9057\u4f20\u5b66\u4e2d\u7528\u6765\u643a\u5e26\u8150\u8349\u9709\u7d20\u6297\u6027\u57fa\u56e0\u6bd4\u5982Sh ble\u57fa\u56e0\u7684\u8f6c\u67d3\u7ec6\u80de\u3002<\/span><\/p>\n

\u8150\u8349\u9709\u7d20\uff08Phleomycin\uff09\u4e0eZeocin\u2122\u6709\u6548\u6210\u5206\u57fa\u672c\u5dee\u4e0d\u591a\uff0c\u4f46\u6709\u6240\u5dee\u5f02\uff0c\u8150\u8349\u9709\u7d20\uff08Phleomycin\uff09\u5efa\u8bae\u7528\u4e8e\u5bf9Zeocin\u2122\u654f\u611f\u6027\u6bd4\u8f83\u5dee\u7684\u7ec6\u80de\uff0c\u6bd4\u5982\uff1a\u4e1d\u72b6\u771f\u83cc\u548c\u67d0\u4e9b\u9175\u6bcd\u83cc\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

\u4e09\u3001\u56db\u79cd\u5316\u5408\u7269\u7684\u4ea7\u54c1\u4fe1\u606f\u3010\u6211\u53f8\u61cb\u5eb7\u751f\u7269maokangbio\u63d0\u4f9b\u4ee5\u4e0a\u56db\u79cd\u4ea7\u54c1\u7684\u535a\u83b1\u9709\u7d20\u5bb6\u65cf\u5316\u5408\u7269\uff0c\u73b0\u8d27\u4f9b\u5e94\uff0c\u6b22\u8fce\u8ba2\u8d2d\u6216\u6765\u7535\u8d44\u6599\uff0c021-54736159\u3011<\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\u8d27\u53f7<\/span><\/td>\n\u540d\u79f0<\/span><\/td>\n\u89c4\u683c<\/span><\/td>\nCAS NO.<\/span><\/td>\n<\/tr>\n
MS0008-1ML<\/span><\/td>\nPhleomycin (20mg\/ml) \u8150\u8349\u9709\u7d20\uff0820 mg\/ml\uff09 <\/a><\/span><\/td>\n1ml<\/span><\/td>\n11006-33-0<\/span><\/td>\n<\/tr>\n
MS0008-5ML<\/span><\/td>\nPhleomycin (20mg\/ml) \u8150\u8349\u9709\u7d20\uff0820 mg\/ml\uff09 <\/a><\/span><\/td>\n5\u00d71ml<\/span><\/td>\n11006-33-0<\/span><\/td>\n<\/tr>\n
MS0009-125MG<\/span><\/td>\nZeocin (100mg\/ml)\u00a0\u535a\u83b1\u9709\u7d20\uff08100 mg\/ml\uff09 <\/a><\/span><\/td>\n125mg<\/span><\/td>\n11006-33-0<\/span><\/td>\n<\/tr>\n
MS0009-1000MG<\/span><\/td>\nZeocin (100mg\/ml)\u00a0\u535a\u83b1\u9709\u7d20\uff08100 mg\/ml\uff09 <\/a><\/span><\/td>\n8\u00d7125mg<\/span><\/td>\n11006-33-0<\/span><\/td>\n<\/tr>\n
MZ3504-10MG<\/span><\/td>\nBleomycin Sulfate \u786b\u9178\u535a\u83b1\u9709\u7d20 <\/a><\/span><\/td>\n10mg<\/span><\/td>\n9041-93-4<\/span><\/td>\n<\/tr>\n
MZ3504-50MG<\/span><\/td>\nBleomycin Sulfate \u786b\u9178\u535a\u83b1\u9709\u7d20 <\/a><\/span><\/td>\n50mg<\/span><\/td>\n9041-93-4<\/span><\/td>\n<\/tr>\n
MZ3506-10MG<\/span><\/td>\nBleomycin A5 Hydrochloride \u76d0\u9178\u535a\u83b1\u9709\u7d20A5\uff08\u5e73\u9633\u9709\u7d20) \u00a0 <\/a><\/span><\/td>\n10mg<\/span><\/td>\n121032-29-9<\/span><\/td>\n<\/tr>\n
MZ3506-50MG<\/span><\/td>\nBleomycin A5 Hydrochloride \u76d0\u9178\u535a\u83b1\u9709\u7d20A5\uff08\u5e73\u9633\u9709\u7d20) <\/a><\/span><\/td>\n50mg<\/span><\/td>\n121032-29-9<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n

\u00a0\u2014 \u2014Written\/Edited by V. Shallan\u3010\u7248\u6743\u5f52\u96c6\u5947\u751f\u7269\/MKBio\u61cb\u5eb7\u6240\u6709\u3011<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u535a\u83b1\u9709\u7d20\uff08\u535a\u6765\u9709\u7d20\uff09\uff08Bleomycins, BLMs\uff09\uff0c\u7531\u8f6e\u679d\u94fe\u9709\u83cc\uff08Streptomyces verticillus\uff09\u4ee3\u8c22\u4ea7\u751f\u7684\u4e00\u79cd\u6297\u80bf\u7624\u7cd6\u80bd\u6297\u751f\u7d20\uff0c\u662f\u4e34\u5e8a\u4e0a\u76f8\u5173\u7684\u5929\u7136\u4ea7\u7269\uff0c\u7528\u4e8e\u5316\u7597\u6cbb\u7597\u6dcb\u5df4\u7624\u3001\u9cde\u72b6\u7ec6\u80de\u764c\u548c\u777e\u4e38\u764c\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52],"tags":[],"_links":{"self":[{"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/posts\/17459"}],"collection":[{"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/comments?post=17459"}],"version-history":[{"count":0,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/posts\/17459\/revisions"}],"wp:attachment":[{"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/media?parent=17459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/categories?post=17459"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.562part.com\/wp-json\/wp\/v2\/tags?post=17459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}